Animal Models of Exfoliation Syndrome, Now and Future
نویسندگان
چکیده
منابع مشابه
Animal models of exfoliation syndrome, now and future.
At present, no animal models fully embody exfoliation syndrome or exfoliation glaucoma. Both genetic and environmental factors appear critical for disease manifestation, and both must be considered when generating animal models. Because mice provide a powerful mammalian platform for modeling complex disease, this paper focuses on mouse models of exfoliation syndrome and exfoliation glaucoma.
متن کاملFipronil: mechanisms of action on various organisms and future relevance for animal models studies
Because insects had developed resistance to several insecticides, today, neonicotinoids and fiproles are used to combat pests. The difference between this two classes of insecticides is that fipronil acts by inhibiting the receptors of nervous cells, while neonicotinoids perturbs the neuronal transmission. The suitable properties of fipronil make that its use to be more obvious on the pesticide...
متن کاملAnimal Models Of Liver Cirrhosis And Fibrosis
Animal modeling is a crucial necessity in clinical studies of liver diseases. Authenticity of the data which are produced using this tool under different conditions and accuracy of the analyses and assessments which would be based on such data sets is completely dependent on the adoption of a standardized methodology for analyzes and assessment of these data sets. Cirrhosis and Fibrosis are amo...
متن کاملManaging Bardet–Biedl Syndrome—Now and in the Future
Bardet-Biedl syndrome is a rare autosomal recessive multisystem disorder caused by defects in genes encoding for proteins that localize to the primary cilium/basal body complex. Twenty-one disease-causing genes have been identified to date. It is one of the most well-studied conditions in the family of diseases caused by defective cilia collectively known as ciliopathies. In this review, we pro...
متن کاملAnimal models of Williams syndrome.
In recent years, researchers have generated a variety of mouse models in an attempt to dissect the contribution of individual genes to the complex phenotype associated with Williams syndrome (WS). The mouse genome is easily manipulated to produce animals that are copies of humans with genetic conditions, be it with null mutations, hypomorphic mutations, point mutations, or even large deletions ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Glaucoma
سال: 2014
ISSN: 1057-0829
DOI: 10.1097/ijg.0000000000000121